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Invitrogen™ UVRAG Polyclonal Antibody
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Catalog No. PIPA597066
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100 μL
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PIPA597066 100 μL
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Catalog No. PIPA597066 Supplier Invitrogen™ Supplier No. PA597066
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KGHRKRASSE NERLQYKTPP PSYNSALAQP VTTVPSMGET ERKITSLSSS LDTSLDFSKE NKKKGEDLVG SLNGGHANVH PSQEQGEALS GHRATVNGTL LPSEQAGSAS VQLPGEFHPV SEAELCCTVE QAEEIIGLEA TGFASGDQLE AFNCIPVDSA VAVECDEQVL GEFEEFSRRI YALNENVSSF RRPRRSSDK; Positive Samples: LO2, HeLa, Mouse liver, Rat liver, Rat brain; Cellular Location: Chromosome, Early endosome, Endoplasmic reticulum, Late endosome, Lysosome, Midbody, centromere.

UVRAG is predicted to contain a coiled-coil structure and is likely to be metabolically unstable based on the occurrence of a strong PEST domain. It interacts with Beclin 1, leading to activation of autophagy and thereof inhibition of tumorigenicity of human colon cancer cells. The gene for UVRAG protein is localized on human chromosome 11q13. 5 and complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells. The gene has been extremely well conserved during evolution, implying an important role for this gene product in cell metabolism. Chromosomal aberrations involving this gene are associated with left-right axis malformation, and mutations in this gene have been associated with colon cancer. The protein is highly expressed in human brain, lung, kidney and liver.
TRUSTED_SUSTAINABILITY

Specifications

Antigen UVRAG
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 2.31 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Uvrag
Gene Accession No. Q8K245, Q9P2Y5
Gene Alias 9530039D02Rik; AI648770; BB124205; beclin 1 binding protein; DHTX; disrupted in heterotaxy; hypothetical protein; p63; UV radiation resistance associated; UV radiation resistance associated gene; UV radiation resistance-associated gene protein; UV radiation resistance-associated protein; UVRAG; Uvrag1; Uvragl; VPS38
Gene Symbols Uvrag
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 501-699 of human UVRAG (NP_0033602).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 308846, 7405, 78610
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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