UVRAG Polyclonal Antibody, Bethyl Laboratories

Catalog No.	Quantity
50-157-2359	100 μL
50-157-2360	10 μL

Catalog No. 50-157-2359 Supplier Bethyl Laboratories, Inc Supplier No. IHC00590

Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine, Horse, Rabbit, Guinea pig_10141, Pig, Panda, Orangutan, Gorilla, Chimpanzee,

UVRAG is predicted to contain a coiled-coil structure and is likely to be metabolically unstable based on the occurrence of a strong PEST domain. It interacts with Beclin 1, leading to activation of autophagy and thereof inhibition of tumorigenicity of human colon cancer cells. The gene for UVRAG protein is localized on human chromosome 11q13.5 and complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells. The gene has been extremely well conserved during evolution, implying an important role for this gene product in cell metabolism. Chromosomal aberrations involving this gene are associated with left-right axis malformation, and mutations in this gene have been associated with colon cancer. The protein is highly expressed in human brain, lung, kidney and liver.

Specifications

• Antigen: UVRAG
• Applications: Immunohistochemistry
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene: UVRAG
• Gene Accession No.: Q8K245, Q9P2Y5
• Gene Alias: DHTX, VPS38, p63, UV radiation resistance-associated gene protein, beclin 1 binding protein, disrupted in heterotaxy
• Gene Symbols: Uvrag
• Host Species: Rabbit
• Immunogen: Between 649 and 699
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7405, 78610
• Target Species: Human, Mouse
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG