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Invitrogen™ UVRAG Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA535213
Description
UVRAG Polyclonal Antibody for Western Blot, ICC/IF, IHC (P)
UVRAG is predicted to contain a coiled-coil structure and is likely to be metabolically unstable based on the occurrence of a strong PEST domain. It interacts with Beclin 1, leading to activation of autophagy and thereof inhibition of tumorigenicity of human colon cancer cells. The gene for UVRAG protein is localized on human chromosome 11q13. 5 and complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells. The gene has been extremely well conserved during evolution, implying an important role for this gene product in cell metabolism. Chromosomal aberrations involving this gene are associated with left-right axis malformation, and mutations in this gene have been associated with colon cancer. The protein is highly expressed in human brain, lung, kidney and liver.
Specifications
UVRAG | |
Polyclonal | |
Unconjugated | |
Uvrag | |
9530039D02Rik; AI648770; BB124205; beclin 1 binding protein; DHTX; disrupted in heterotaxy; hypothetical protein; p63; UV radiation resistance associated; UV radiation resistance associated gene; UV radiation resistance-associated gene protein; UV radiation resistance-associated protein; UVRAG; Uvrag1; Uvragl; VPS38 | |
Rabbit | |
Ammonium Sulfate Precipitation, Size-exclusion - Dialysis | |
RUO | |
7405, 78610 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Western Blot | |
2 mg/mL | |
PBS with 0.09% sodium azide; pH 7.4 | |
Q8K245, Q9P2Y5 | |
Uvrag | |
KLH conjugated synthetic peptide between 666-699 amino acids from the C-terminal region of human UVRAG. | |
400 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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