Invitrogen™ UVRAG Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA535213

Catalog No. PIPA535213

Description

UVRAG Polyclonal Antibody for Western Blot, ICC/IF, IHC (P)

UVRAG is predicted to contain a coiled-coil structure and is likely to be metabolically unstable based on the occurrence of a strong PEST domain. It interacts with Beclin 1, leading to activation of autophagy and thereof inhibition of tumorigenicity of human colon cancer cells. The gene for UVRAG protein is localized on human chromosome 11q13. 5 and complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells. The gene has been extremely well conserved during evolution, implying an important role for this gene product in cell metabolism. Chromosomal aberrations involving this gene are associated with left-right axis malformation, and mutations in this gene have been associated with colon cancer. The protein is highly expressed in human brain, lung, kidney and liver.

Specifications

• Antigen: UVRAG
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Uvrag
• Gene Alias: 9530039D02Rik; AI648770; BB124205; beclin 1 binding protein; DHTX; disrupted in heterotaxy; hypothetical protein; p63; UV radiation resistance associated; UV radiation resistance associated gene; UV radiation resistance-associated gene protein; UV radiation resistance-associated protein; UVRAG; Uvrag1; Uvragl; VPS38
• Host Species: Rabbit
• Purification Method: Ammonium Sulfate Precipitation, Size-exclusion - Dialysis
• Regulatory Status: RUO
• Gene ID (Entrez): 7405, 78610
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Western Blot
• Concentration: 2 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q8K245, Q9P2Y5
• Gene Symbols: Uvrag
• Immunogen: KLH conjugated synthetic peptide between 666-699 amino acids from the C-terminal region of human UVRAG.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov