Invitrogen™ V-ATPase C1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA566075

Catalog No. PIPA566075

Description

Immunogen sequence: VVVPKLNHNDW IKQYETLAEM VVPRSSNVLS EDQDSYLCNV TLFRKAVDDF RHKARENKFI VRDFQYNEEE MKADKEEMNR Highest antigen sequence identity to the following orthologs - mouse 99%, rat 98%.

ATP6V1C1 is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D.

Specifications

• Antigen: V-ATPase C1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ATP6V1C1
• Gene Alias: 1700025B18Rik; ATP6C; Atp6c1; ATP6D; Atp6v1c1; ATPase H+ transporting V1 subunit C1; ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1; ATPase, H+ transporting, lysosomal V1 subunit C1; ATPase, H+ transporting, V1 subunit C, isoform 1; FLJ20057; H(+)-transporting two-sector ATPase, subunit C; H+ -ATPase C subunit; H+-transporting ATPase chain C, vacuolar; subunit C of vacuolar proton-ATPase V1 domain; testicular tissue protein Li 223; U13839; vacuolar ATP synthase subunit C; vacuolar H+ -ATPase C subunit; vacuolar proton pump C subunit; vacuolar proton pump subunit C 1; vacuolar proton pump, 42-kD subunit; vacuolar proton-ATPase, subunit C, VI domain; vatC; V-ATPase C subunit; V-ATPase subunit C 1; Vma5; V-type proton ATPase subunit C 1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 528
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P21283
• Gene Symbols: ATP6V1C1
• Immunogen: Recombinant Human V-ATPase C1. Recombinant protein control fragment (Product #RP-105065).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov