Invitrogen™ v-Myb Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552611

Catalog No. PIPA552611

Description

Immunogen sequence: EANAVLSSLQ TIPEFAETLE LIESDPVAWS DVTSFDISDA AASPIKSTPV KLMRIQHNEG AMECQFNVSL VLEGKKNTCN GGNSEAVPLT SPNIAKFSTP PAILRKKRKM RVGHSPGSEL RDGSLNDGGN Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 85%.

A-Myb is expressed at specific times in reproductive tissues, some neural cells, and a subset of normal and neoplastic B lymphocytes. Both A-Myb and B-Myb are expressed in t(14:18) lymphoma cells where they then inhibit cell arrest and apoptotic signaling. Expression of B-Myb rescues cells from p53-induced G1 phase arrest that is mediated by p21, while A-Myb functions as an anti-apoptotic factor by effectively activating the bcl-2 promoter and thereby up-regulating Bcl-2 expression.

Specifications

• Antigen: v-Myb
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MYBL1
• Gene Alias: AMYB; A-myb; G1-419-6; MYB proto-oncogene like 1; MYBA; MYBL1; myb-like protein 1; Myb-related protein A; myeloblastosis oncogene-like 1; repro9; VMYB; v-myb avian myeloblastosis viral oncogene homolog-like 1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4603
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P10243
• Gene Symbols: MYBL1
• Immunogen: Recombinant protein corresponding to Human v-Myb. Recombinant protein control fragment (Product #RP-89420).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov