Invitrogen™ VAMP1/VAMP2 Monoclonal Antibody (SP10)

Catalog No.	Quantity
PIMA517608	200 μg

Catalog No. PIMA517608 Supplier Invitrogen™ Supplier No. MA517608

Description

Mouse Monoclonal Antibody

MA5-17608 targets VAMP/synaptobrevin in ELISA, FACS, and WB applications and shows reactivity with Human samples. The MA5-17608 immunogen is human Synaptobrevin 1 (aa 1-118) and Synaptobrevin 2(aa 33-96).

Vesicle-associated membrane protein 2 is essential for cAMP-regulated exocytosis. VAMP (also know as synaptobrevin) is part of the synaptic vesicle docking and fusion complex and plays a central role in neuroexocytosis. Two VAMP (vesicle-associated membrane protein) isoforms are expressed in the nervous system and are differently distributed among the specialized parts of the tissue. VAMP-1 and -2 are present in all tissues tested, including kidney, adrenal gland, liver, pancreas, thyroid, heart, and smooth muscle. The two isoforms are differentially expressed in various tissues and their level may depend on differentiation. VAMP-1 is restricted to exocrine pancreas and to kidney tubular cells, whereas VAMP-2 is the predominant isoform present in Langerhans islets and in glomerular cells. Both isoforms show a patchy vesicular intracellular distribution in confocal microscopy. Evidence for the importance of neuronal VAMPproteins in the physiology of all cells is indicated.

Specifications

• Antigen: VAMP1/VAMP2
• Applications: ELISA, Flow Cytometry, Western Blot
• Classification: Monoclonal
• Clone: SP10
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.02% sodium azide
• Gene: VAMP1
• Gene Accession No.: P23763, P63027
• Gene Alias: RATVAMPB; RATVAMPIR; SPAX1; SYB; SYB1; SYB2; synaptobrevin 1; synaptobrevin 2; Synaptobrevin 2 (vesicle-associated membrane protein VAMP-2); synaptobrevin-1; Synaptobrevin-2; Vamp1; VAMP-1; VAMP2; VAMP-2; vesicle associated membrane protein 1; vesicle associated membrane protein 2; Vesicle-associated membrane protein (synaptobrevin 2); vesicle-associated membrane protein 1; vesicle-associated membrane protein 1 (synaptobrevin 1); vesicle-associated membrane protein 2; vesicle-associated membrane protein 2 (synaptobrevin 2)
• Gene Symbols: VAMP1, VAMP2
• Host Species: Mouse
• Immunogen: Human Synaptobrevin 1 (aa 1-118) and Synaptobrevin 2(aa 33-96).
• Purification Method: Affinity chromatography
• Quantity: 200 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 6843, 6844
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgM