Invitrogen™ VAMP2 Monoclonal Antibody (GT6311)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA535929

Catalog No. PIMA535929

Description

VAMP2 Monoclonal Antibody for Western Blot, ICC/IF, IHC (P)

The vesicle associated membrane proteins (VAMP) or synaptobrevins are calcium binding proteins specific to eukaryotes. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP-25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. In Alzheimer's disease, VAMP levels of all isoforms appear to be significantly lowered. It is suggested that VAMP-2 is a resident protein of the insulin-sensitive glucose transporter type 4 (GLUT4) compartment and that it is required for GLUT4 vesicle incorporation into the cell surface in response to insulin.

Specifications

• Antigen: VAMP2
• Classification: Monoclonal
• Concentration: 1.74 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: P63027, P63044, P63045
• Gene Symbols: VAMP2
• Immunogen: Full length human VAMP2 Recombinant protein.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: GT6311
• Conjugate: Unconjugated
• Gene: VAMP2
• Gene Alias: RATVAMPB; RATVAMPIR; SYB; SYB2; Syb-2; sybII; Synaptobrevin; synaptobrevin 2; Synaptobrevin 2 (vesicle-associated membrane protein VAMP-2); synaptobrevin II; synaptobrevin-2; vamp; Vamp2; VAMP-2; vesicle associated membrane protein 2; vesicle-associated membrane 2; Vesicle-associated membrane protein (synaptobrevin 2); vesicle-associated membrane protein 2; vesicle-associated membrane protein 2 (synaptobrevin 2)
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 22318, 24803, 6844
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid