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Invitrogen™ VAMP2 Monoclonal Antibody (GT6311)
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Catalog No. PIMA535929
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100 μL
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PIMA535929 100 μL
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Catalog No. PIMA535929 Supplier Invitrogen™ Supplier No. MA535929
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Description

Mouse Monoclonal Antibody

VAMP2 Monoclonal Antibody for Western Blot, ICC/IF, IHC (P)

The vesicle associated membrane proteins (VAMP) or synaptobrevins are calcium binding proteins specific to eukaryotes. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP-25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. In Alzheimer's disease, VAMP levels of all isoforms appear to be significantly lowered. It is suggested that VAMP-2 is a resident protein of the insulin-sensitive glucose transporter type 4 (GLUT4) compartment and that it is required for GLUT4 vesicle incorporation into the cell surface in response to insulin.
TRUSTED_SUSTAINABILITY

Specifications

Antigen VAMP2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone GT6311
Concentration 1.74 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene VAMP2
Gene Accession No. P63027, P63044, P63045
Gene Alias RATVAMPB; RATVAMPIR; SYB; SYB2; Syb-2; sybII; Synaptobrevin; synaptobrevin 2; Synaptobrevin 2 (vesicle-associated membrane protein VAMP-2); synaptobrevin II; synaptobrevin-2; vamp; Vamp2; VAMP-2; vesicle associated membrane protein 2; vesicle-associated membrane 2; Vesicle-associated membrane protein (synaptobrevin 2); vesicle-associated membrane protein 2; vesicle-associated membrane protein 2 (synaptobrevin 2)
Gene Symbols VAMP2
Host Species Mouse
Immunogen Full length human VAMP2 Recombinant protein.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22318, 24803, 6844
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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