Vancomycin Hydrochloride, MP Biomedicals™

Description

Indicated for the treatment of serious infections caused by methicillin-resistant strains. Vancomycin Hydrochloride, MP Biomedicals is a glycopeptide antibiotic that blocks bacterial cell wall biosynthesis at the level of peptidoglycan biosynthesis. It is

Vancomycin, from Streptomyces orientalis, block bacterial cell wall biosynthesis by inhibiting incorporation of terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides. It also alters bacterial-cell-membrane permeability and RNA synthesis. It is widely studied in cancer patients.

Vancomycin is effective against Gram-positive bacteria. It is only indicated for the treatment of serious, life-threatening infections that are unresponsive to other less-toxic antibiotics. In particular, it is used to treat infections caused by susceptible strains of methicillin-resistant (β-lactam-resistant) staphylococci bacteria. It should not be used to treat methicillin-sensitive Staphylococcus aureus, because it is inferior to penicillins such as nafcillin.

Specifications

• Physical Form: Powder
• CAS: 123409-00-7
• pH: 2.5 to 4.5 (5% aq. soln.)
• Source: Streptomyces orientalis
• Potency: ca. 1000μg/mg
• Quantity: 100 mg
• Molecular Formula: C66H257Cl2N9O24
• Solubility Information: Soluble in water (>100 mg/mL). Moderately soluble in dilute methanol. Insoluble in acetone, alcohols, and ether.
• InChI Key: ARNOCQCQWLXLRG-UHFFFAOYSA-N
• SMILES: C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.C.CC(C1=CC(=C(C=C1)OC2CC(C(C(O2)CO)O)O)OC3=CC=CC=C3)NC(=O)C.C(=O)O.N.N.N.N.N.N.N.N.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.Cl.Cl
• IUPAC Name: azane;N-[1-[4-[4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-phenoxyphenyl]ethyl]acetamide;formic acid;methane;pentadecahydrate;dihydrochloride
• Molecular Weight (g/mol): 1632.721
• PubChem CID: 44134997
• Formula Weight: 1485.7