VANGL1 Monoclonal Antibody (CL0241), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA524592

Catalog No. PIMA524592

Description

Immunogen sequence: DTESTYSGYS YYSSHSKKSH RQGERTRERH KSPRNKDGRG SEKSVTIQPP TGEPLLGNDS TRTEEVQDDN WGETTTAITG TSEHSISQED IARISKDMED SVGLDCKRY Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.

Vang-like 1 protein is a novel human homologue of Drosophila Van Gogh/Strabismus. The Vang-like 1 gene consists of at least 7 exons, and encodes a protein with four transmembrane domains and the C-terminal Ser/Thr-X-Val motif. Studies shows that the expression of the protein is significantly up-regulated in gastric cancer cell lines MKN28, MKN74, pancreatic cancer cell lines BxPC-3, PSN-1 and Hs766T. The protein may serve as an effector mediating the intestinal trefoil factor (ITF) healing response of the intestinal mucosa. The protein also serves as a diagnostic marker for hepatocellular carcinoma as well as a potential molecular target for development of novel therapeutic drugs. The pathological role of the protein has been identified in neural tube defects (NTD). Human Vang-like 1 gene maps to chromosome 1p11-p13.1.

Specifications

• Antigen: VANGL1
• Classification: Monoclonal
• Concentration: 0.7 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8TAA9
• Gene Symbols: VANGL1
• Immunogen: Recombinant protein corresponding to Human VANGL1
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunocytochemistry, Western Blot
• Clone: CL0241
• Conjugate: Unconjugated
• Gene: VANGL1
• Gene Alias: KAI1 COOH-terminal interacting tetraspanin; KAI1 C-terminal interacting tetraspanin; Kitenin; Loop-tail protein 2; loop-tail protein 2 homolog; LPP2; STB2; Stbm; STBM2; strabismus; strabismus 2; Van Gogh-like protein 1; vang, van gogh-like 1; VANGL planar cell polarity protein 1; Vangl1; vang-like 1 (van gogh, Drosophila); vang-like protein 1
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 81839
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

Research Use Only