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Invitrogen™ VANGL1 Monoclonal Antibody (CL0241)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA524592
Description
Immunogen sequence: DTESTYSGYS YYSSHSKKSH RQGERTRERH KSPRNKDGRG SEKSVTIQPP TGEPLLGNDS TRTEEVQDDN WGETTTAITG TSEHSISQED IARISKDMED SVGLDCKRY Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.
Vang-like 1 protein is a novel human homologue of Drosophila Van Gogh/Strabismus. The Vang-like 1 gene consists of at least 7 exons, and encodes a protein with four transmembrane domains and the C-terminal Ser/Thr-X-Val motif. Studies shows that the expression of the protein is significantly up-regulated in gastric cancer cell lines MKN28, MKN74, pancreatic cancer cell lines BxPC-3, PSN-1 and Hs766T. The protein may serve as an effector mediating the intestinal trefoil factor (ITF) healing response of the intestinal mucosa. The protein also serves as a diagnostic marker for hepatocellular carcinoma as well as a potential molecular target for development of novel therapeutic drugs. The pathological role of the protein has been identified in neural tube defects (NTD). Human Vang-like 1 gene maps to chromosome 1p11-p13.1.
Specifications
VANGL1 | |
Monoclonal | |
0.7 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q8TAA9 | |
VANGL1 | |
Recombinant protein corresponding to Human VANGL1. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG1 |
Western Blot, Immunocytochemistry | |
CL0241 | |
Unconjugated | |
VANGL1 | |
KAI1 COOH-terminal interacting tetraspanin; KAI1 C-terminal interacting tetraspanin; Kitenin; Loop-tail protein 2; loop-tail protein 2 homolog; LPP2; STB2; Stbm; STBM2; strabismus; strabismus 2; Van Gogh-like protein 1; vang, van gogh-like 1; VANGL planar cell polarity protein 1; Vangl1; vang-like 1 (van gogh, Drosophila); vang-like protein 1 | |
Mouse | |
Protein A | |
RUO | |
81839 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
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