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Invitrogen™ VANGL1 Polyclonal Antibody
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Catalog No. PIPA5101954
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PIPA5101954 100 μL
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Catalog No. PIPA5101954 Supplier Invitrogen™ Supplier No. PA5101954
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total VANGL1.

Vang-like 1 protein is a novel human homologue of Drosophila Van Gogh/Strabismus. The Vang-like 1 gene consists of at least 7 exons, and encodes a protein with four transmembrane domains and the C-terminal Ser/Thr-X-Val motif. Studies shows that the expression of the protein is significantly up-regulated in gastric cancer cell lines MKN28, MKN74, pancreatic cancer cell lines BxPC-3, PSN-1 and Hs766T. The protein may serve as an effector mediating the intestinal trefoil factor (ITF) healing response of the intestinal mucosa. The protein also serves as a diagnostic marker for hepatocellular carcinoma as well as a potential molecular target for development of novel therapeutic drugs. The pathological role of the protein has been identified in neural tube defects (NTD). Human Vang-like 1 gene maps to chromosome 1p11-p13.1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen VANGL1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene VANGL1
Gene Accession No. Q80Z96, Q8TAA9
Gene Alias KAI1 COOH-terminal interacting tetraspanin; KAI1 C-terminal interacting tetraspanin; Kitenin; Loop-tail protein 2; loop-tail protein 2 homolog; LPP2; STB2; Stbm; STBM2; strabismus; strabismus 2; Van Gogh-like protein 1; vang, van gogh-like 1; VANGL planar cell polarity protein 1; Vangl1; vang-like 1 (van gogh, Drosophila); vang-like protein 1
Gene Symbols VANGL1
Host Species Rabbit
Immunogen A synthesized peptide derived from human VANGL1(Accession Q8TAA9), corresponding to amino acid residues R352-A402.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 229658, 81839
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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