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Invitrogen™ VANGL2 Polyclonal Antibody
Goat Polyclonal Antibody
Supplier: Invitrogen™ PA518654
Description
This antibody is predicted to react with bovine and zebrafish based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
Van Gogh is an alternate name for the Drosophila strabismus protein. Van Gogh like-2 (VANGL2) is a 521 amino acidprotein in vertebrates similar to strabismus 1 of Drosophila and a component of the frizzled-disheveled tissue polarity pathway. It interacts through it's C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3 and is a potent tumor suppressor. It ispredominantly involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. It plays a crucial role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. VANGL2 is required for polarization and movement of myocardializing cells and seems to act via RHOA signaling to regulate this process. It is expressed in a wide range of tissues.
Specifications
VANGL2 | |
Polyclonal | |
Unconjugated | |
Vangl2 | |
C530001F03Rik; KIAA1215; loop tail associated protein; loop-tail; Loop-tail protein 1; loop-tail protein 1 homolog; Loop-tail-associated protein; Lp; LPP1; Ltap; MGC119403; MGC119404; RGD:1309442}; ska>m17Jus>; ska17; STB1; stbm; STBM1; strabismus; Strabismus 1; van Gogh-like protein 2; vang; vang (van gogh)-like 2; Vang1l2; VANGL planar cell polarity protein 2; Vangl2; vangl2 {ECO:0000312; vang-like 2 (van gogh, Drosophila); vang-like protein 2 | |
Goat | |
Ammonium Sulfate Precipitation | |
RUO | |
93840 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
Western Blot | |
0.5 mg/mL | |
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3 | |
Q91ZD4 | |
Vangl2 | |
Synthetic peptide sequence (QKYLRTTKQQPYH) corresponding to the internal amino acids of VANGL2 (aa 403-416). | |
100 μg | |
Primary | |
Mouse | |
Antibody | |
IgG |
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