Invitrogen™ VAP-1 Monoclonal Antibody (TK8-14), eBioscience™

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ BMS1033

Catalog No. 50-177-00

Description

Description: VAP-1 (TK8-14) is a mouse monoclonal antibody raised against affinity purifiedVAP-1 from tonsil stroma of human origin. Lymphocyte binding to vascular endothelium is a prerequisite for the move-ment of immune cells from the blood into lymphoid tissues and into sites ofinflammation. Under inflammatory conditions, cell surface expression ofVAP-1 (vascular adhesion protein-1) which is an endothelial sialoglycoprotein,is induced. VAP-1 is a type II transmembrane protein of 84.6 kDa with a singletransmembrane domain and N and O-glycosylation sites in the extracellulardomain. In vivo, VAP-1 exists predominantly as a 180 kDa homodimer andfunctions both as an enzyme (monoamine oxidase) and an adhesion moleculefor lymphocytes. Applications Tested: ELISA, Flow Cytometry, Immunofluorescence, Western Blotting.

Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The product is a major protein on the adipocyte plasma membrane. It has adhesive properties and also has functional monoamine oxidase activity. A pseudogene for this gene has been discribed and is located approximately 9-kb downstream.

Specifications

• Antigen: VAP-1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative; pH 7.2-7.4
• Gene Accession No.: Q16853
• Gene Symbols: AOC3
• Immunogen: Rec. Human VAP-1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: ELISA, Flow Cytometry, Immunohistochemistry, Western Blot
• Clone: TK8-14
• Conjugate: Unconjugated
• Gene: AOC3
• Gene Alias: amine oxidase, copper containing 3; amine oxidase, copper containing 3 (vascular adhesion protein 1); Aoc3; Copper amine oxidase; HPAO; Membrane primary amine oxidase; placenta copper monamine oxidase; semicarbazide-sensitive amine oxidase; SSAO; VAP1; VAP-1; Vascular adhesion protein 1; VP97
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8639
• Content And Storage: -20°C
• Form: Liquid

Safety and Handling

WARNING: Cancer and Reproductive Harm - www.P65Warnings.ca.gov