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  5. Tocris Bioscience™ VAS 2870

Tocris Bioscience™ VAS 2870
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Catalog No. 66545
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25 mg
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66-545 5 mg
66-542-5RD 25 mg
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Catalog No. 66-545 Supplier Tocris Bioscience™ Supplier No. 6654/5
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Description

NADPH oxidase (Nox) inhibitor

VAS 2870 is a NADPH oxidase (Nox) inhibitor. Inhibits PMA-stimulated oxidative burst in HL-60 cells (IC50 = 2 μM). Inhibits oxidized-LDL-mediated, but not basal, ROS production in HUVECs in vitro. Also inhibits PDGF-mediated Nox activation and ROS formation in vascular smooth muscle cells (VSMCs) and abolishes PDGF-dependent migration of VSMCs, while having no effect on proliferation. Enhances TGF-β-induced apoptosis of liver tumor cells. Also inhibits platelet aggregation through a NOX-independent mechanism.

Specifications

Chemical Name or Material 7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine
CAS 722456-31-7
Quantity 5 mg
Molecular Formula C18H12N6OS
Formula Weight 360.39
Purity 98%
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