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VASH1 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501983412
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100 μL
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50-198-3412 100 μL
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Catalog No. 50-198-3412 Supplier Bioss Supplier No. BS1505R
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Description

Rabbit Polyclonal Antibody

VASH1 was originally identified as an endothelium-derived vascular endothelial growth factor (VEGF)-inducible angiogenesis inhibitor that acts in a negative feedback manner. VASH1 mRNA is expressed brain, heart, kidney and placenta in the adult, with robust expression in various organs during embryonic development. VASH1 expression in tumor cells and tumor vasculature is silenced by methylation by increased expression of Zeste homolog 2 (EZH2). The increase of EZH2 expression is induced by VEGF stimulation, leading to poor clinical prognosis. Recombinant adenovirus expressing VASH prevented tumor angiogenesis and inhibited tumor growth, suggesting that it may be a potentially valuable antitumor therapy in the clinic.

Specifications

Antigen VASH1
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene VASH1
Gene Accession No. Q7L8A9
Gene Alias AI834978; D930046M13Rik; G630009D10Rik; KIAA1036; RGD1564082; TTCP 1; Tubulin carboxypeptidase 1; Tubulinyl-Tyr carboxypeptidase 1; Tyrosine carboxypeptidase 1; Vash; VASH1; vasohibin 1; Vasohibin-1
Gene Symbols VASH1
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human VASH1.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22846
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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