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Invitrogen™ VASN Polyclonal Antibody
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Catalog No. PIPA552808
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100 μL
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PIPA552808 100 μL
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Catalog No. PIPA552808 Supplier Invitrogen™ Supplier No. PA552808
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LCPEGFTGLY CESQMGQGTR PSPTPVTPRP PRSLTLGIEP VSPTSLRVGL QRYLQGSSVQ LRSLRLTYRN LSGPDKRLVT LRLPASLAEY TVTQLRPNAT YSVCVMPLGP GRVPEGEEAC GEAHTPPAVH SNH Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 83%.

The VASN gene encodes the protein vasorin, a type I transmembrane protein involved in cellular signaling, vascular development, and tissue repair. Vasorin is characterized by its expression in various tissues, including vascular endothelial cells and smooth muscle cells, where it functions to modulate cell proliferation and differentiation. It plays a significant role in the regulation of vascular remodeling and homeostasis by interacting with signaling molecules like transforming growth factor-beta (TGF-β), thereby influencing processes such as angiogenesis and wound healing. Vasorin is implicated in inhibiting TGF-β signaling pathways, which are crucial for maintaining vascular integrity and preventing excessive fibrosis during tissue repair. Dysregulation of VASN expression can contribute to pathological conditions, including cardiovascular diseases and cancer, where abnormal vascular remodeling and cell proliferation are evident. Research into vasorin continues to explore its functional mechanisms and potential therapeutic applications in diseases characterized by vascular dysregulation and tissue remodeling.
TRUSTED_SUSTAINABILITY

Specifications

Antigen VASN
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene VASN
Gene Accession No. Q6EMK4
Gene Alias 2610528G05Rik; Atia; Protein slit-like 2; Slitl2; Slit-like 2; UNQ314/PRO357/PRO1282; VASN; Vasorin
Gene Symbols VASN
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human VASN. Recombinant protein control fragment (Product #RP-89934).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114990
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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