Invitrogen™ VASN Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110822

Catalog No. PIPA5110822

Description

Immunogen sequence: LDVSNLSLQA LPGDLSGLFP RLRLLAAARN PFNCVCPLSW FGPWVRESHV TLASPEETRC HFPPKNAGRL LLELDYADFG CPATTTTATV PTTRPVVREP TALSSSLAPT.

The VASN gene encodes the protein vasorin, a type I transmembrane protein involved in cellular signaling, vascular development, and tissue repair. Vasorin is characterized by its expression in various tissues, including vascular endothelial cells and smooth muscle cells, where it functions to modulate cell proliferation and differentiation. It plays a significant role in the regulation of vascular remodeling and homeostasis by interacting with signaling molecules like transforming growth factor-beta (TGF-β), thereby influencing processes such as angiogenesis and wound healing. Vasorin is implicated in inhibiting TGF-β signaling pathways, which are crucial for maintaining vascular integrity and preventing excessive fibrosis during tissue repair. Dysregulation of VASN expression can contribute to pathological conditions, including cardiovascular diseases and cancer, where abnormal vascular remodeling and cell proliferation are evident. Research into vasorin continues to explore its functional mechanisms and potential therapeutic applications in diseases characterized by vascular dysregulation and tissue remodeling.

Specifications

• Antigen: VASN
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: VASN
• Gene Alias: 2610528G05Rik; Atia; Protein slit-like 2; Slitl2; Slit-like 2; UNQ314/PRO357/PRO1282; VASN; Vasorin
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 114990
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6EMK4
• Gene Symbols: VASN
• Immunogen: Recombinant Protein corresonding to Human VASN. Recombinant protein control fragment (Product #RP-108312).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG