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Invitrogen™ VAV1 Monoclonal Antibody (2E11)
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Catalog No. PIMA517198
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100 μg
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Catalog No. Quantity
PIMA517198 100 μg
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Catalog No. PIMA517198 Supplier Invitrogen™ Supplier No. MA517198
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Description

Mouse Monoclonal Antibody

MA5-17198 targets VAV1 in FACS, indirect ELISA, and WB applications and shows reactivity with Human samples. The MA5-17198 immunogen is purified recombinant fragment of human VAV1 (amino acids: 121-324) expressed in E. Coli. MA5-17198 detects VAV1 which has a predicted molecular weight of approximately 98.3kDa.

The VAV1 gene, located on chromosome 19p13.2, encodes for a protein that functions as a guanine nucleotide exchange factor (GEF). Structurally, the VAV1 protein contains several functional domains, including Dbl homology (DH) and pleckstrin homology (PH) domains, which facilitate its role in exchange activity, and SH3 and SH2 domains, critical for signal transduction. VAV1 is primarily expressed in hematopoietic cells and plays a crucial role in the regulation of immune responses, particularly in T-cell receptor signaling. It influences actin cytoskeleton reorganization, cell proliferation, and differentiation, making it vital for proper immune system function.
TRUSTED_SUSTAINABILITY

Specifications

Antigen VAV1
Applications ELISA, Flow Cytometry, Western Blot
Classification Monoclonal
Clone 2E11
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene VAV1
Gene Accession No. P15498
Gene Alias oncogene vav; p95; p95vav; Proto-oncogene vav; VAV; vav 1 guanine nucleotide exchange factor; vav 1 oncogene; vav guanine nucleotide exchange factor 1; vav oncogene; vav proto-oncogene; VAV1; vav-T
Gene Symbols VAV1
Host Species Mouse
Immunogen Purified recombinant fragment of human VAV1 (amino acids: 121-324) expressed in E. Coli.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7409
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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