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Invitrogen™ VAV1 Polyclonal Antibody
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Catalog No. PIPA581980
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PIPA581980 100 μL
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Catalog No. PIPA581980 Supplier Invitrogen™ Supplier No. PA581980
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LSWTPIAQNR GIMPFPTEEE SVGDEDIYSG LSDQIDDTVE EDEDLYDCVE NEEAEGDEIY EDLMRSEPVS MPPKMTEYDK RCCCLREIQQ TEEKYTDTLG SIQQHFLKPL QRFLKPQDIE IIFINIEDLL RVHTHFLKEM KEAL Highest antigen sequence indentity to the following orthologs: Mouse - 86%, Rat - 88%.

The VAV1 gene, located on chromosome 19p13.2, encodes for a protein that functions as a guanine nucleotide exchange factor (GEF). Structurally, the VAV1 protein contains several functional domains, including Dbl homology (DH) and pleckstrin homology (PH) domains, which facilitate its role in exchange activity, and SH3 and SH2 domains, critical for signal transduction. VAV1 is primarily expressed in hematopoietic cells and plays a crucial role in the regulation of immune responses, particularly in T-cell receptor signaling. It influences actin cytoskeleton reorganization, cell proliferation, and differentiation, making it vital for proper immune system function.
TRUSTED_SUSTAINABILITY

Specifications

Antigen VAV1
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene VAV1
Gene Accession No. P15498
Gene Alias oncogene vav; p95; p95vav; Proto-oncogene vav; VAV; vav 1 guanine nucleotide exchange factor; vav 1 oncogene; vav guanine nucleotide exchange factor 1; vav oncogene; vav proto-oncogene; VAV1; vav-T
Gene Symbols VAV1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human VAV1. Recombinant protein control fragment (Product #RP-94785).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7409
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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