Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
VCAM1 Monoclonal Antibody (OTI4F1), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Supplier: OriGene TA502361
Description
VCAM-1 (vascular cell adhesion protein 1, CD106, INCAM-110) is a cell surface sialoglycoprotein expressed by cytokine activated endothelium. VCAM-1 has a number of functions including the regulation of leukocyte migration, leukocyte-endothelial cell adhesion and signal transduction and may play a role in a number of inflammatory diseases. VCAM-1 is distributed across non-leukocyte and leukocyte cells. VCAM-1 expression is reportedly correlated with adhesion of melanoma, Burkitt lymphoma, osteosarcoma, and kidney carcinoma but not colon carcinoma cells to endothelial cells which may determine the site of tumor metastasis. VCAM-1 is a member of the Ig superfamily of adhesion molecules, is expressed at high levels on cytokine stimulated vascular endothelial cells, and at minimal levels on unstimulated endothelial cells. VCAM-1 is also present on follicular and inter-follicular dendritic cells of lymph nodes, myoblasts, and some macrophages. VCAM-1 serves as a ligand for leukocyte integrin alpha-beta (VLA-4 or CD49d/CD29) and mediates cell adhesion of leukocytes to activated endothelium. VCAM-1 plays a role in tumor metastasis, and may also be involved in the development of atherosclerosis and rheumatoid arthritis. Two alternatively spliced transcripts encoding different isoforms of VCAM-1 have been described.Specifications
VCAM1 | |
Monoclonal | |
0.36 mg/mL | |
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
P19320 | |
VCAM1 | |
Full length human recombit protein of human VCAM1 produced in HEK293T cell. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG1 |
Western Blot | |
OTI4F1 | |
Unconjugated | |
VCAM1 | |
CD106, INCAM-100 | |
Mouse | |
Affinity Chromatography | |
RUO | |
7412 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
Provide Content Correction
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?
Provide Content Correction