Invitrogen™ VDAC Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA585405

Catalog No. PIPA585405

Description

Keep as concentrated solution. Predicted reactivity: Mouse (97%), Rat (97%), Xenopus laevis (85%), Pig (98%), Rabbit (99%), Chicken (93%), Sheep (99%), Rhesus Monkey (98%), Bovine (99%). Positive Control: A431, H1299, HeLa, HepG2, F05, F32, F39, F90. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Voltage-dependent anion channel (VDAC) proteins are abundant, pore-forming proteins belonging to the eukaryotic mitochondrial porins. It was discovered in the mitochondrial outer membrane. It also is expressed in the plasma membrane. At least three different VDAC genes have been identified in vertebrates. VDAC proteins are known to play an essential role in cellular metabolism and in the early stages of apoptosis. For example, VDAC constitutes a major pathway by which metabolites such as ADP/ATP, succinate and citrate are exchanged between the cytosol and mitochondria. And VDAC1 in the plasma membrane establishes a novel level of apoptosis regulation putatively via its redox activity.

Specifications

• Antigen: VDAC
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: VDAC1
• Gene Alias: AL033343; BR1-VDAC; Brain-derived voltage-dependent anion channel 1; hVDAC1; MGC111064; Mitochondrial outer membrane protein porin 1; Mitochondrial Porin; mVDAC1; mVDAC5; N2441; OMP2; Outer mitochondrial membrane protein porin 1; plasmalemmal porin; POR1; PORIN; Porin 31HL; porin 31HM; porin POR1; PORIN-31-HL; rVDAC1; VD; VDAC; VDAC1; VDAC-1; Vdac5; VDAC-5; voltage dependent anion channel 1; voltage-dependent anion channel 1; voltage-dependent anion-selective channel protein 1; Voltage-dependent anion-selective channel protein 5; YNL055C; YNL2441C
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22333, 7416, 83529
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1.46 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: P21796, Q60932, Q9Z2L0
• Gene Symbols: VDAC1
• Immunogen: Recombinant protein encompassing a sequence within the center region of human VDAC1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov