VDAC/PorinRabbit anti-Bovine, Goat, Human, Mouse, Porcine, Rat, Polyclonal, Rockland™

Catalog No.	Quantity
50-199-1838	100 μL

Catalog No. 50-199-1838 Supplier Rockland Immunochemicals Supplier No. 600401882RTU

Description

Rabbit Polyclonal Antibody

Store vial at 2-8°C prior to opening. May aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. Dilute only prior to use. RTU Anti-VDAC/Porin Antibody is directed against human VDAC1/Porin1 protein. A BLAST analysis was used to suggest that this antibody would react with VDAC1/Porin1 from a wide range or organisms, including avian, mammalian, aquatic and reptilian sources based on 100% homology for the immunogen sequence. Cross reactivity will occur with all forms of VDACs including VDAC1, VDAC2 (4 isoforms) and VDAC3 (2 isoforms). Such broad reactivity makes this antibody useful as an excellent loading control (mitochondrial).

Voltage-dependent anion channel (VDAC) proteins are abundant, pore-forming proteins belonging to the eukaryotic mitochondrial porins. It was discovered in the mitochondrial outer membrane. It also is expressed in the plasma membrane. At least three different VDAC genes have been identified in vertebrates. VDAC proteins are known to play an essential role in cellular metabolism and in the early stages of apoptosis. For example, VDAC constitutes a major pathway by which metabolites such as ADP/ATP, succinate and citrate are exchanged between the cytosol and mitochondria. And VDAC1 in the plasma membrane establishes a novel level of apoptosis regulation putatively via its redox activity.

Specifications

• Antigen: VDAC/Porin
• Applications: ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: 0.02M potassium phosphate with 0.01% BSA, 0.15M NaCl, 25% glycerol and 0.01% sodium azide; pH 7.2
• Gene: VDAC1
• Gene Accession No.: P21796, P45879, Q60932, Q9MZ16, Q9Z2L0
• Gene Alias: AL033343; hVDAC1; MGC111064; Mitochondrial outer membrane protein porin 1; Mitochondrial Porin; mVDAC1; mVDAC5; N2441; OMP2; Outer mitochondrial membrane protein porin 1; Plasmalemmal porin; POR1; PORIN; Porin 31HL; Porin 31HM; porin POR1; PORIN-31-HL; rVDAC1; VD; VDAC; Vdac1; VDAC-1; Vdac5; VDAC-5; voltage dependent anion channel 1; voltage-dependent anion channel 1; Voltage-dependent anion-selective channel protein 1; Voltage-dependent anion-selective channel protein 5; YNL055C; YNL2441C
• Gene Symbols: VDAC1
• Host Species: Rabbit
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 102173290, 22333, 282119, 397010, 7416, 83529
• Target Species: Bovine, Goat, Human, Mouse, Pig, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid