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Tocris Bioscience™ VE 821
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Quantity:
5 mg
Description
VE 821 is a high affinity and selective ATP-competitive ATR inhibitor (Ki = 13 nM). Exhibits >75-fold selectivity for ATR over related kinases mTOR, DNA-PK, PI 3-Kγ and PIKKs (Ki values are >1, 2.2, 3.9 and 16 μM, respectively) and a panel of other kinases. Induces cell death in colon cancer cell lines in vitro and sensitizes tumor cells to treatment with DNA damaging anticancer agents.
Specifications
Specifications
Chemical Name or Material | 3-Amino-6-[4-(methlsulfonyl)phenyl)-N-phenyl-2-pyrazinecarboxamide |
CAS | 1232410-49-9 |
Quantity | 5 mg |
Molecular Formula | C18H16N4O3S |
Formula Weight | 368.41 |
Purity | 98% |
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