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  5. Tocris Bioscience™ VE 821

Tocris Bioscience™ VE 821

Catalog No. 61605
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Quantity:
5 mg
Catalog No. Quantity
61-605 5 mg
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Catalog No. 61-605

Supplier: Tocris Bioscience™ 6160/5

This item is not returnable. View return policy

Description

High affinity and selective ATP-competitive ATR inhibitor (Ki = 13 nM)

VE 821 is a high affinity and selective ATP-competitive ATR inhibitor (Ki = 13 nM). Exhibits >75-fold selectivity for ATR over related kinases mTOR, DNA-PK, PI 3-Kγ and PIKKs (Ki values are >1, 2.2, 3.9 and 16 μM, respectively) and a panel of other kinases. Induces cell death in colon cancer cell lines in vitro and sensitizes tumor cells to treatment with DNA damaging anticancer agents.

Specifications

Chemical Name or Material 3-Amino-6-[4-(methlsulfonyl)phenyl)-N-phenyl-2-pyrazinecarboxamide
CAS 1232410-49-9
Quantity 5 mg
Molecular Formula C18H16N4O3S
Formula Weight 368.41
Purity 98%
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