MilliporeSigma™ VEGF, Rabbit, Alexa Fluor 488, Polyclonal,

Catalog No.	Quantity	Conjugate
ABS82AF488	100 μL	Alexa Fluor 488

Catalog No. ABS82AF488 Supplier MilliporeSigma™ Supplier No. ABS82AF488

Description

Rabbit Polyclonal Antibody

Keratin, type I cytoskeletal 18 (UniProt P05783; also known as Cell proliferation-inducing gene 46 protein, CK-18, Cytokeratin-18, K18, Keratin-18) is encoded by the KRT18 (also known as CYK18, PIG46) gene (Gene ID 3875) in human. Cytokeratin-18 (Keratin-18 or K18) belongs to a family of highly conserved epithelial-specific intermediate filament (IF) proteins that play an important role in the mechanical stability and integrity of epithelial cells and tissues. Each epithelium is characterized by its unique keratin expression pattern. All epithelial cells typically express at least one type-I and one type-II keratin, which form noncovalent heteropolymers. Keratin 18 is a type I intermediate filament protein that pairs with keratin 8 (K8/K18) in simple epithelia and plays an important role in protecting cells from stress, injury, and apoptosis. K18 is the only type-I keratin in adult hepatocytes and the major type-I keratin in many colonic tumor cell lines.The structure and function of K8/18 are regulated by posttranslational modifications, such as glycosylation, ubiquitination, and phosphorylation, including K8 phosphorylation on Ser8, Ser23, Ser73, Ser431, and K18 phosphorylation on Ser33 and Ser52. K18 phosphorylation has been proposed as a progression marker for human chronic hepatitis B (CHB). Progressively higher Ser52 phosphorylation is reported in non-cirrhotic and cirrhotic CHB livers, and progressive increase of Ser33 and Ser52 phosphorylation correlates with the elevation of both histological lesions and enzymatic activities of alanine aminotransferase in non-cirrhotic CHB livers.

Specifications

• Antigen: VEGF
• Applications: Immunocytochemistry
• Classification: Polyclonal
• Concentration: Please refer to lot specific datasheet.
• Conjugate: Alexa Fluor 488
• Formulation: Purified rabbit polyclonal antibody conjugate in PBS with 15mg/ml BSA and 0.1 % Sodium Azide.
• Gene: VEGFA, VEGF
• Gene Accession No.: P15692
• Host Species: Rabbit
• Immunogen: KLH-conjugated linear peptide corresponding to human VEGF at the N-terminus.
• Purification Method: Affinity Purified
• Quantity: 100 μL
• Regulatory Status: RUO
• Research Discipline: Signaling
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_001020537
• Test Specificity: This antibody recognizes VEGF at the N-terminus.
• Target Species: Human
• Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
• Form: Purified
• Isotype: IgG

For Research Use Only. Not for use in diagnostic procedures.