Invitrogen™ VEGF Receptor 1 (Flt1) Monoclonal Antibody (Flt-19), eBioscience™

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ BMS196

Catalog No. 50-178-54

Description

Description: BMS196 reacts specifically with the extracellular domain of human VEGF Receptor-1. The epitope recognized by BMS196 resides within a.a. residues 1-251 of the VEGF-R1. The antibody does not recognize VEGF-R2. Applications Tested: ELISA, Immunohistochemistry, Immunoprecipitation.

FLT1 (VEGFR1) is a receptor tyrosine kinase which plays a critical role in angiogenesis. Active angiogenesis has been found to play important role in many pathological and physiological processes, such as tumor progression, diabetic retinopathy, rheumatoid arthritis and wound healing. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR.

Specifications

• Antigen: VEGF Receptor 1 (Flt1)
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: Tissue culture supernatant with 10% FBS and no preservative
• Gene Accession No.: P17948
• Gene Symbols: FLT1
• Immunogen: Rec. Human VEGF-R1 (FLT-1).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Immunohistochemistry, Immunoprecipitation
• Clone: Flt-19
• Conjugate: Unconjugated
• Gene: FLT1
• Gene Alias: AI323757; embryonic receptor kinase 2; Emrk2; FLT; FLT1; FLT-1; fms related tyrosine kinase 1; FMS-like tyrosine kinase 1; FMS-related tyrosine kinase 1; Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); FRT; i21; sFlt1; soluble VEGFR 1; sVEGFR 1; Tyrosine-protein kinase FRT; tyrosine-protein kinase receptor FLT; Vascular endothelial growth factor receptor 1; vascular endothelial growth factor receptor-1; vascular permeability factor receptor; VEGF R1; VEGFR1; VEGFR-1
• Host Species: Mouse
• Purification Method: Purified
• Regulatory Status: RUO
• Gene ID (Entrez): 2321
• Content And Storage: -20°C
• Form: Liquid

Safety and Handling

WARNING: Cancer and Reproductive Harm - www.P65Warnings.ca.gov