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Invitrogen™ VEGF Receptor 1 Monoclonal Antibody (CL0345)
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Catalog No. PIMA534979
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100 μL
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PIMA534979 100 μL
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Catalog No. PIMA534979 Supplier Invitrogen™ Supplier No. MA534979
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Description

Mouse Monoclonal Antibody

Immunogen sequence: LNLTIMNVSL QDSGTYACRA RNVYTGEEIL QKKEITIRDQ EAPYLLRNLS DHTVAISSST TLDCHANGVP EPQITWFKNN HKIQQEPGII LGPGSSTLFI ERVTEEDEGV YHCKATNQKG S Highest antigen sequence indentity to the following orthologs: Rat - 82%, Mouse - 80%.

FLT1 (VEGFR1) is a receptor tyrosine kinase which plays a critical role in angiogenesis. Active angiogenesis has been found to play important role in many pathological and physiological processes, such as tumor progression, diabetic retinopathy, rheumatoid arthritis and wound healing. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR.
TRUSTED_SUSTAINABILITY

Specifications

Antigen VEGF Receptor 1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone CL0345
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene FLT1
Gene Accession No. P17948
Gene Alias AI323757; embryonic receptor kinase 2; Emrk2; FLT; FLT1; FLT-1; fms related tyrosine kinase 1; FMS-like tyrosine kinase 1; FMS-related tyrosine kinase 1; Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); FRT; i21; sFlt1; soluble VEGFR 1; sVEGFR 1; Tyrosine-protein kinase FRT; tyrosine-protein kinase receptor FLT; Vascular endothelial growth factor receptor 1; vascular endothelial growth factor receptor-1; vascular permeability factor receptor; VEGF R1; VEGFR1; VEGFR-1
Gene Symbols FLT1
Host Species Mouse
Immunogen Recombinant protein fragment of Human FLT1 (Product #RP-108143)
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2321
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2b
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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