Invitrogen™ VEGF Receptor 2 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA120207

Catalog No. PA120207

Description

Neutralization: Anti-Mouse VEGF Receptor 2 has the ability to neutralize the biological activity of recombinant mouse VEGF Receptor 2 on HUVE (human umbilical vein endothelial) cells in the presence of recombinant mouse VEGF Receptor 2/Fc (50 ng/mL) and recombinant mouse VEGF (5 ng/mL). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

KDR (FLK1, VEGFR2) is a type III receptor tyrosine kinase. It binds vascular endothelial growth factor with high affinity in vitro, and is expressed early in development by endothelial cell precursors. FLK1 (VEGF Receptor 2) encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of FLK1 (VEGF Receptor 2) are implicated in infantile capillary hemangiomas.

Specifications

• Antigen: VEGF Receptor 2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KDR
• Gene Alias: 6130401C07; CD309; CD309 antigen; fetal liver kinase 1; fetal liver kinase-1; FLK1; Flk-1; FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2); FLK1 kinase insert domain receptor (VEGF receptor 2); flk-1 type VEGF receptor; KDR; kinase insert domain protein receptor; kinase insert domain receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); kinase NYK; Krd-1; Ly73; protein-tyrosine kinase receptor flk-1; sCD309; soluble CD309; soluble vascular endothelial growth factor receptor 2; soluble VEGFR 2; soluble VEGFR2; sVEGFR-2; tyrosine kinase growth factor receptor; vascular endotheial growth factor 2; vascular endothelial growth factor receptor 2; vascular endothelial growth factor receptor- 2; vascular endothelial growth factor receptor-2; vascular endothelial growth factor receptor-3; VEGF R2; VEGF receptor-2; VEGFR; VEGFR2; VEGFR-2
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16542
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry, Neutralization, Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: P35918
• Gene Symbols: KDR
• Immunogen: Recombinant extracellular domain of mouse VEGF receptor 2, expressed in mouse NSO cells.
• Quantity: 25 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG