VEGFR2/KDR/Flk-1 Antibody (KDR657), Novus Biologicals™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
NBP233000A	Novus Biologicals NBP2330000.1MG	0.1 mg
NBP233000B	Novus Biologicals NBP2330000.2MG	0.2 mg

Description

VEGFR2/KDR/Flk-1 Monoclonal specifically detects VEGFR2/KDR/Flk-1 in Human samples. It is validated for Flow Cytometry.

Specifications

• Antigen: VEGF R2/KDR/Flk-1
• Dilution: Flow Cytometry 0.5 - 1ug/million cells in 0.1ml, Immunofluorescence 0.5 - 1ug/ml
• Classification: Monoclonal
• Form: Purified
• Regulatory Status: RUO
• Target Species: Human
• Gene Accession No.: P35968
• Gene ID (Entrez): 3791
• Immunogen: Recombinant human VEGF-R2 protein
• Primary or Secondary: Primary
• Content And Storage: Store at 4C.

• Clone: KDR657
• Applications: Flow Cytometry, Immunofluorescence
• Conjugate: Unconjugated
• Host Species: Mouse
• Research Discipline: Angiogenesis, Cancer, Cellular Markers, Endothelial Cell Markers, Hematopoietic Stem Cell Markers, HIF Target Genes, Hypoxia, Phospho Specific, Signal Transduction, Stem Cell Markers, Tumor Suppressors, Tyrosine Kinases
• Formulation: PBS with 0.05% BSA. with 0.05% Sodium Azide
• Gene Alias: CD309, CD309 antigen, EC 2.7.10, EC 2.7.10.1, Fetal liver kinase 1, fetal liver kinase-1, FLK-1, FLK1tyrosine kinase growth factor receptor, Kinase insert domain receptor, kinase insert domain receptor (a type III receptor tyrosine kinase), Protein-tyrosine kinase receptor flk-1, soluble VEGFR2, vascular endothelial growth factor receptor 2, VEGFR, VEGFR2, VEGFR-2
• Gene Symbols: KDR
• Isotype: IgG1 κ
• Purification Method: Protein A purified
• Test Specificity: CD309, also known as VEGF-R2, KDR3, and Flk-1 (mouse), is a type I transmembrane glycoprotein. It is a member of the CSF-1/PDGF receptor family of type III tyrosine kinase receptors. Human VEGF-R2 is mainly expressed by endothelial cells, embryonic tissues, and megakaryocytes. It plays an important role in the regulation of angiogenesis, vasculogenesis, and vascular permeability. The ligands of VEGF-R2 include VEGF-A, VEGF-C, VEGF-D, and VEGF splice isoforms. Ligation of VEGF-R2 with its ligands results in the receptor dimerization and auto-phosphorylation, stimulating endothelial cell proliferation and migration.