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Tocris Bioscience™ Veliparib dihydrochloride
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Catalog No. 702650
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70-265-0 50 mg
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Catalog No. 70-265-0 Supplier Tocris Bioscience™ Supplier No. 7026/50
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Description

High affinity PARP-1 and -2 inhibitor; orally bioavailable

Veliparib dihydrochloride is a high affinity PARP-2 and PARP-1 inhibitor (Ki values are 2.9 and 5.2 nM, respectively). Inhibits repair of radiation-induced DNA damage and sensitizes lung cancer cells to radiation. Also increases autophagy and apoptosis in lung cancer cells. Enhances radiation-induced tumor growth delay in mice bearing lung tumor xenografts. Also chemosensitizer. Potentiates effects of temozolomide (Cat. No. 2706) in a mouse melanoma model. Orally bioavailable and brain penetrant.

Specifications

Chemical Name or Material 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-4-carboxamide dihydrochloride
CAS 912445-05-7
Quantity 50 mg
Molecular Formula C13H16N4O.2HCl
Purity 98%
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