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Tocris Bioscience™ Vemurafenib
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Catalog No. 730910
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73-091-0 10 mg
73-095-0 50 mg
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Catalog No. 73-091-0 Supplier Tocris Bioscience™ Supplier No. 7309/10
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Description

Potent BRAF and CRAF inhibitor

Vemurafenib is a potent inhibitor of BRAFV600E, C-Raf and wild type B-Raf (IC50 values are 13-31 nM, 6.7-48 nM and 100-160 nM, respectively. Vemurafenib also inhibits SRMS, ACK1 KHS1, FGR (IC50 values are 18 nM, 19 nM, 51 nM and 63 nM, respectively). Vemurafenib shows antitumor activity and induces autophagy in BRAF-mutant thyroid cancer cells.

Specifications

Chemical Name or Material N-[3-[[5-(4-Chlorophenyl)-1 H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
CAS 918504-65-1
Quantity 10 mg
Target Raf Kinase Inhibitors
Molecular Formula C23H18ClF2N3O3S
Purity 0.98
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