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Invitrogen™ Versican Monoclonal Antibody (N351/23), PE
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Catalog No. PIMA545626
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100 μg
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PIMA545626 100 μg
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Catalog No. PIMA545626 Supplier Invitrogen™ Supplier No. MA545626
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Description

Mouse Monoclonal Antibody

1 μg/mL of MA5-45626 was sufficient for detection of Versican in 20 μg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Detects >350kDa. This antibody was formerly sold as clone S351-23.

Versican is a member of the family of large aggregating proteoglycans (also including aggrecan, brevican, and neurocan). The protein shows wide tissue distribution which includes fibrous, articular, and elastic cartilages, as well as nervous, epidermal, arterial, and loose connective tissues. Versican V1 has been shown to enhance cell proliferation, and also induce cell transformation and protect cells from apoptosis. This was demonstrated through its ability to downregulate the expression of proapoptotic Bad. Versican's existence as a extracellular matrix protein in human airways has also lead to the discovery of an inflammatory role in asthmatics.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Versican
Applications Western Blot, Immunocytochemistry
Classification Monoclonal
Clone N351/23
Concentration 1 mg/mL
Conjugate PE
Formulation 2.48mM MES, 95.46mM phosphate with 2mM EDTA and no preservative; pH 7.4
Gene VCAN
Gene Accession No. P13611, Q62059, Q9ERB4
Gene Alias 5430420N07Rik; 9430051N09; Chondroitin sulfate proteoglycan 2; chondroitin sulfate proteoglycan 2 (versican); chondroitin sulfate proteoglycan core protein 2; Cspg2; DPEAAE; ERVR; GHAP; glial hyaluronate-binding protein; hdf; heart defect; large fibroblast proteoglycan; NG2; PGM; PG-M; PG-M core protein; PG-M(V0); PG-M(V1); V1 Neo; VCAN; versican; versican core protein; Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M); versican proteoglycan; Versican V0; WGN; WGN 1; WGN1
Gene Symbols VCAN
Host Species Mouse
Immunogen Fusion protein amino acids 362-585 (glycosaminoglycan alpha domain) of mouse Versican core protein.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114122, 13003, 1462
Target Species Human, Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
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