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  5. Tocris Bioscience™ Verubecestat

Tocris Bioscience™ Verubecestat
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Catalog No. 765950
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

BACE1 and BACE2 inhibitor

Verubecestat is a high affinity and selective β-secretase 1 (BACE1) and its homolog BACE2 inhibitor (Ki of 2.2 nM and 0.38 nM respectively). It exhibits no inhibition of cathepsin D, cathepsin E, pepsin, or renin. Verubecestat potently reduces Aβ40 formation in HEK293 APPSwe/Lon cells (IC50 = 2.1 nM). Verubecestat significantly lowers CSF and brain Aβ levels in rats. Orally bioavailable.

Specifications

Chemical Name or Material N-[3-[(5 R)-3-Amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2 H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide
CAS 1286770-55-5
Quantity 50 mg
Target Secretase Inhibitors
Molecular Formula C17H17F2N5O3S
Purity 0.98
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