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Invitrogen™ VGLL2 Polyclonal Antibody
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Catalog No. PIPA575941
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100 μL
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PIPA575941 100 μL
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Catalog No. PIPA575941 Supplier Invitrogen™ Supplier No. PA575941
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Description

Rabbit Polyclonal Antibody

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

VGLL2 is the master regulator in the wing development in Drosophila, which acts through a complex by interacting with scalloped, a homolog of vertebrate TEF proteins. Northern and dot blot analyses of human adult tissues detected VGLL2 expression in skeletal muscle. In situ hybridization revealed VGLL2 expression in differentiating somites and branchial arches during mouse embryogenesis. VITO1 is the clone of VGLL2. It contains a scalloped interaction domain (SID). VITO1 is more highly expressed in differentiated myotubes from the mouse C2C12 myogenic cell line than in undifferentiated cells. During differentiation in mouse C2C12 cell line, VGLL2 mRNA levels increase and VGLL2 protein translocates from the cytoplasm to the nucleus. Interference with VITO1 expression by small interfering RNA attenuated differentiation in C2C12 muscle cells. Therefore, this protein is an important component of the myogenic program.
TRUSTED_SUSTAINABILITY

Specifications

Antigen VGLL2
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene VGLL2
Gene Accession No. Q8BGW8, Q8N8G2
Gene Alias C130057C21Rik; Protein VITO1; RP1-179P9.2; Transcription cofactor vestigial-like protein 2; Vestigial and Tondu related protein 1; vestigial like 2; vestigial like 2 homolog; vestigial like 2 homolog (Drosophila); vestigial like family member 2; vestigial-like 2; vestigial-like family member 2; Vgl2; vgl-2; Vgll2; Vito1; VITO-1
Gene Symbols VGLL2
Host Species Rabbit
Immunogen Synthetic peptide corresponding to amino acids 34-79 of Human VGLL2.
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 215031, 245806, 309772
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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