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  5. Tocris Bioscience™ VH 298

Tocris Bioscience™ VH 298
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Catalog No. 615610
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Catalog No. Quantity
61-561-0 10 mg
61-565-0 50 mg
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Description

High-affinity inhibitor of VHL

VH 298 is a high-affinity inhibitor of E3 ubiquitin ligase VHL (Kd = 80-90 nM). Blocks interaction between VHL and HIF-α downstream of HIF-α hydroxylation, initiating hypoxic response. Results in time- and concentration-dependent accumulation of hydroxylated HIF-α, and upregulates mRNA and protein levels of HIF target genes, with similar transcriptional profile to hypoxia. Cell permeable.

Negative control cis VH 298 also available.

Specifications

Quantity 10 mg
Target Ubiquitin Ligase (E3)
Molecular Formula C27H33N5O4S
Formula Weight 523.65g/mol
Product Type Inhibitor

For Research Use Only

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