VHL Mouse anti-Human, Clone: OTI1E1, liquid, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene TA506222
DescriptionVon Hippel-Lindau syndrome (VHL) is a domitly inherited familial cancer syndrome predisposing to a variety of maligt and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
|Full length human recombit protein of human VHL produced in HEK293T cell.|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide|
|HRCA1, RCA1, VHL1, pVHL|
|-20° C, Avoid Freeze/Thaw Cycles|
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