VHL Mouse anti-Human, Clone: OTI1E1, liquid, TrueMAB™

Catalog No.	Quantity
50-167-6540	100 μL

Catalog No. 50-167-6540 Supplier OriGene Supplier No. TA506222

Description

Mouse Monoclonal Antibody

Von Hippel-Lindau syndrome (VHL) is a domitly inherited familial cancer syndrome predisposing to a variety of maligt and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Specifications

• Antigen: VHL
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: OTI1E1
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: VHL
• Gene Accession No.: P40337
• Gene Alias: HRCA1, RCA1, VHL1, pVHL
• Gene Symbols: VHL
• Host Species: Mouse
• Immunogen: Full length human recombit protein of human VHL produced in HEK293T cell.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7428
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b