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Invitrogen™ VHL Polyclonal Antibody
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Catalog No. PIPA5116114
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100 μL
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PIPA5116114 100 μL
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Catalog No. PIPA5116114 Supplier Invitrogen™ Supplier No. PA5116114
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total VHL.

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
TRUSTED_SUSTAINABILITY

Specifications

Antigen VHL
Applications Immunohistochemistry (PFA fixed), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene VHL
Gene Accession No. P40337, P40338, Q64259
Gene Alias elongin binding protein; HRCA1; Protein G7; pVHL; RCA1; VHL; VHL1; VHL19; Vhlh; VHLp18(MEA); Von Hippel Lindau; von hippel-lindau; von Hippel-Lindau disease tumor suppressor; von Hippel-Lindau syndrome homolog; von Hippel-Lindau syndrome protein homolog; von Hippel-Lindau tumor suppressor; von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
Gene Symbols VHL
Host Species Rabbit
Immunogen A synthesized peptide derived from human VHL(Accession P40337), corresponding to amino acid residues E42-D92.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22346, 24874, 7428
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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