Invitrogen™ VHLL Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA571282

Catalog No. PIPA571282

Description

This target displays homology in the following species: Human: 100%.

Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha.

Specifications

• Antigen: VHLL
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: VHLL
• Gene Alias: VHL pseudogene; VHLL; VHL-like protein; VHLP; VLP; von Hippel-Lindau tumor suppressor like; von Hippel-Lindau tumor suppressor-like; von Hippel-Lindau-like protein
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 391104
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q6RSH7
• Gene Symbols: VHLL
• Immunogen: synthetic peptide directed towards the N-terminal region of human VHLL.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG