Vimentin Antibody Cocktail, Invitrogen™

Catalog No.	Quantity
PIMA514435	7 mL

Catalog No. PIMA514435 Supplier Thermo Scientific Supplier No. MA514435

Description

Antibody Cocktail

MA5-14435 targets Vimentin in IHC (P) applications and shows reactivity with Human samples. The MA5-14435 immunogen is vimentin - recombinant protein encoding human Vimentin, gp100 - Extract of pigmented melanoma metastases from lymph nodes. Host/Isotype: Rabbit/Mouse / IgG/IgG1, kappa

Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Unlike other IFP proteins, vimentin is expressed, along with desmin, during the early stages of cellular development. During the development process, vimentin is exchanged for new, tissue-specific IFPs. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles leading to an increase in steroid synthesis.

Specifications

• Antigen: Vimentin
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Cocktail
• Clone: Vimentin-SP20, gp100-HMB45, gp100-HMB45
• Conjugate: Unconjugated
• Formulation: proprietary buffer with <0.1% sodium azide
• Gene: Vim
• Gene Accession No.: P08670
• Gene Alias: cb28; class-III intermediate microfilament; CTRCT30; epididymis luminal protein 113; FLJ36605; HEL113; intermediate filament; intermediate filament protein; RP11-124N14.1; similar to vimentin; VIM; VIME; Vimentin; vimentin C-terminus
• Gene Symbols: Vim
• Host Species: Mixed
• Immunogen: Vimentin - recombinant protein encoding human Vimentin, gp100 - Extract of pigmented melanoma metastases from lymph nodes
• Purification Method: purified
• Quantity: 7 mL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7431
• Target Species: Human
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG