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Invitrogen™ Vimentin Monoclonal Antibody (GT7812)
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Catalog No. PIMA531486
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100 μL
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Catalog No. Quantity
PIMA531486 100 μL
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Catalog No. PIMA531486 Supplier Invitrogen™ Supplier No. MA531486
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Description

Mouse Monoclonal Antibody

Keep as concentrated solution. Predicted reactivity: Mouse (98%), Rat (98%), Xenopus laevis (85%), Dog (98%), Chicken (92%), Chimpanzee (99%), Bovine (98%), Guinea pig (97%). Positive Control: 293T, HeLa, C8D30, NIH-3T3, C2C12, U87-MG, SK-N-SH, IMR32, SK-N-AS, NT2D1, rat brain, HEB, A549, H358, MCF10A. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Unlike other IFP proteins, vimentin is expressed, along with desmin, during the early stages of cellular development. During the development process, vimentin is exchanged for new, tissue-specific IFPs. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles leading to an increase in steroid synthesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Vimentin
Applications ELISA, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone GT7812
Concentration 0.64 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene Vim
Gene Accession No. P08670, P20152, P31000
Gene Alias cb28; class-III intermediate microfilament; CTRCT30; epididymis luminal protein 113; FLJ36605; Hel113; intermediate filament; intermediate filament protein; RP11-124N14.1; similar to vimentin; VIM; VIME; Vimentin; vimentin C-terminus
Gene Symbols Vim
Host Species Mouse
Immunogen Recombinant protein encompassing a sequence within the center region of human Vimentin. The exact sequence is proprietary.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22352, 7431, 81818
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a
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