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Invitrogen™ Vimentin Monoclonal Antibody (RV203)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA106908

Catalog No. MA106908


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Description

Description

MA1-06908 detects vimentin in human, rat, goat, canine, hamster and swine samples. MA1-06908 has sucessfully been used in Western blotting, immunocytochemistry and immunohistochemistry (paraffin) procedures. By Western blot it detects a ~57 kDa band representing vimentin. The MA1-06908 immunogen is cytoskeletal vimentin extract of calf lens. Store at 4ºC, or in small aliquots at -20ºC.

Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Unlike other IFP proteins, vimentin is expressed, along with desmin, during the early stages of cellular development. During the development process, vimentin is exchanged for new, tissue-specific IFPs. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles leading to an increase in steroid synthesis.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Vimentin
Monoclonal
1 mg/mL
PBS with 0.09% sodium azide
P02543, P08670, P20152, P31000, P48616, P48670
Vim
Cytoskeletal vimentin extract of calf lens.
100 μL
Primary
Human, Mouse, Rat, Canine, Bovine, Hamster, Pig, Goat
Antibody
IgG1
Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
RV203
Unconjugated
Vim
cb28; class-III intermediate microfilament; CTRCT30; epididymis luminal protein 113; FLJ36605; HEL113; intermediate filament; intermediate filament protein; RP11-124N14.1; similar to vimentin; VIM; VIME; Vimentin; vimentin C-terminus
Mouse
Purified
RUO
100522394, 100689099, 102182515, 22352, 280955, 477991, 7431, 81818
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
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