Vinculin Mouse anti-Human, Mouse, Porcine, Rat, Clone: 2B5A7, Proteintech

Mouse Monoclonal Antibody

Supplier:  Proteintech Group Inc 663051IG150UL

Catalog No. 50-106-0619

Description

Vinculin (VCL) is a cytoskeletal protein associated with cell-cell and cell-extracellular matrix adherens-type junctions. It functions as one of several interacting proteins involved in anchoring F-actin to the membrane. It has been shown that a sequence of molecular interactions might be involved in the transmembrane assembly of adhesion plaques. In the assembly of adhesion plaques, the beta subunit of integrin binds to talin. Talin binds to vinculin that interacts with alpha-actinin and possibly with itself. Since alpha-actinin binds to and cross-links actin filaments, vinculin represents a key element in the transmembrane linkage of the extracellular matrix to the cytoplasmic microfilament system. Mutations in the gene can result in cardiomyopathy dilated 1W or familial hypertrophic 15.

Specifications

• Antigen: Vinculin
• Classification: Monoclonal
• Concentration: 0.78 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P18206, P26234, P85972, Q64727
• Gene Symbols: VCL
• Immunogen: Vinculin Fusion Protein Ag24946
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Pig, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Clone: 2B5A7
• Conjugate: Unconjugated
• Gene: VCL
• Gene Alias: CMD1W, Metavinculin, MVCL, VCL, Vinculin
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 22330, 305679, 396974, 7414
• Content And Storage: -20°C
• Form: Liquid