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Invitrogen™ Viperin Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA565556
Description
Immunogen sequence: YLDILAISCDS FDEEVNVLIG RGQGKKNHVE NLQKLRRWCR DYRVAFKINS VINRFNVEED MTEQIKALNP VRWKVFQCLL IEGENCGEDA L Highest antigen sequence identity to the following orthologs - mouse 91%, rat 91%.
Viperin is a 43kDa protein which is one of several hundred interferon inducible viral proteins. Elevated expression of viperin is induced by LPS and poly I:C through TLR dependent signaling pathways. Sendai virus mediated viperin expression is induced independently of TLR signaling pathways through RLRs - RIG-I and MAVs (Severa, 2006). Viperin has been shown to play an important role in interferon mediated anti-viral activity in a Hepatitis C virus model system (Helbig, 2011). Viperin is induced in lymphoid cells and dendritic cells (DCs) and highly induced in neutrophils and macrophages during acute LCMV infection in mice (Hinson, ). Viperin functions as a mediator of viral resistance and as a marker for interferon responsiveness making its detection and mechanism of action through specific antibody probes valuable for further studies.
Specifications
Viperin | |
Polyclonal | |
Unconjugated | |
Rsad2 | |
2510004L01Rik; Best5; Bone-expressed sequence tag 5 protein; cig33; cig5; CIG6; cytomegalovirus-induced gene 5 protein; hypothetical protein LOC570456; inflammatory response gene 6 protein; inflammatory response protein 6; IRG6; radical S-adenosyl methionine domain containing 2; radical S-adenosyl methionine domain-containing protein 2; rsad2; rsad2 {ECO:0000250; si:ch211-276e8.2; similar to radical S-adenosyl methionine domain containing 2; UniProtKB:Q8WXG1}; VHSV-induced-like protein; Vig1; Viperin; viral hemorrhagic septicemia virus (VHSV)-induced gene 1; virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible; zgc:112342 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
91543 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunocytochemistry | |
0.3 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q8WXG1 | |
Rsad2 | |
Recombinant Human Viperin. Recombinant protein control fragment (Product #RP-106231). | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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