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Invitrogen™ Viperin Polyclonal Antibody
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Catalog No. PIPA523508
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100 μg
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Catalog No. Quantity
PIPA523508 100 μg
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Catalog No. PIPA523508 Supplier Invitrogen™ Supplier No. PA523508
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Description

Rabbit Polyclonal Antibody

The amino acid sequence used as immunogen is 100% homologous in white-cheeked gibbon, chinese hamster, common chimpanzee, new world monkey, panda, african bush elephant and orangutan, 95% in horse, wild turkey, opossum, platypus, 89% in western clawed frog, rabbit, zebra finch, chicken, 79% in carolina anole, and 63% homologous in zebrafish and sablefish.

Viperin is a 43kDa protein which is one of several hundred interferon inducible viral proteins. Elevated expression of viperin is induced by LPS and poly I:C through TLR dependent signaling pathways. Sendai virus mediated viperin expression is induced independently of TLR signaling pathways through RLRs - RIG-I and MAVs (Severa, 2006). Viperin has been shown to play an important role in interferon mediated anti-viral activity in a Hepatitis C virus model system (Helbig, 2011). Viperin is induced in lymphoid cells and dendritic cells (DCs) and highly induced in neutrophils and macrophages during acute LCMV infection in mice (Hinson, ). Viperin functions as a mediator of viral resistance and as a marker for interferon responsiveness making its detection and mechanism of action through specific antibody probes valuable for further studies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Viperin
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA and 0.05% sodium azide
Gene Rsad2
Gene Accession No. O70600, Q2HJF9, Q8CBB9, Q8WXG1, Q9MZU4
Gene Alias 2510004L01Rik; Best5; Bone-expressed sequence tag 5 protein; cig33; cig5; CIG6; cytomegalovirus-induced gene 5 protein; hypothetical protein LOC570456; inflammatory response gene 6 protein; inflammatory response protein 6; IRG6; radical S-adenosyl methionine domain containing 2; radical S-adenosyl methionine domain-containing protein 2; rsad2; rsad2 {ECO:0000250; si:ch211-276e8.2; similar to radical S-adenosyl methionine domain containing 2; UniProtKB:Q8WXG1}; VHSV-induced-like protein; Vig1; Viperin; viral hemorrhagic septicemia virus (VHSV)-induced gene 1; virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible; zgc:112342
Gene Symbols Rsad2
Host Species Rabbit
Immunogen A portion of amino acids 165-215 of human viperin.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100072610, 100347276, 100753921, 396752, 428650, 506415, 58185, 609005, 65190, 91543
Target Species Human, Mouse, Rat, Canine, Rabbit, Monkey, Bovine, Hamster, Pig, Horse, Chicken
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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