VISTA Monoclonal Antibody (B7H5DS8), PE-eFluor™ 610, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
61-108-842	Invitrogen™ 61108842	100 Tests

Description

VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is a product of the VSIR gene. Although VISTA bears sequence homology to PD-L1 it has a different expression pattern. In both mouse and humans, VISTA is expressed predominantly on hematopoietic cells with the highest densities on myeloid cells, and lower levels on T cells. It is usually absent on B cells. VISTA expressed by antigen presenting cells has been shown to directly suppress proliferation and cytokine production of CD4 and CD8 T cells, making it a target for cancer immunotherapy. The reported ligands of VISTA include CD28H, VSIG-3 and VSIG-8.

Specifications

• Antigen: VISTA
• Concentration: 5 μL/Test
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with BSA and 0.09% sodium azide; pH 7.2
• Gene ID (Entrez): 64115
• Immunogen: VISTA-Fc protein.
• Primary or Secondary: Primary
• Product Type: Antibody

• Clone: B7H5DS8
• Applications: Flow Cytometry
• Conjugate: PE-eFluor 610
• Host Species: Mouse
• Target Species: Human
• Gene Accession No.: Q9H7M9
• Gene Symbols: VSIR
• Isotype: IgG1 κ
• Purification Method: Affinity chromatography
• Gene: VSIR