VISTA Monoclonal Antibody (MIH64), Brilliant Ultra Violet™ 737, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Supplier:  Invitrogen 367108382

Catalog No. 50-255-0856

Description

VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is a product of the VSIR gene. Although VISTA bears sequence homology to PD-L1 it has a different expression pattern. In both mouse and humans, VISTA is expressed predominantly on hematopoietic cells with the highest densities on myeloid cells, and lower levels on T cells. It is usually absent on B cells. VISTA expressed by antigen presenting cells has been shown to directly suppress proliferation and cytokine production of CD4 and CD8 T cells, making it a target for cancer immunotherapy. The reported ligands of VISTA include CD28H, VSIG-3 and VSIG-8.

Specifications

• Antigen: VISTA
• Classification: Monoclonal
• Concentration: 0.2 mg/mL
• Formulation: PBS with BSA and 0.09% sodium azide, pH 7.2
• Gene Accession No.: Q9D659
• Gene Symbols: VSIR
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 74048
• Content And Storage: 4°, C, store in dark, DO NOT FREEZE!
• Isotype: IgG2a κ

• Applications: Flow Cytometry
• Clone: MIH64
• Conjugate: Brilliant Ultraviolet 737
• Gene: VSIR
• Gene Alias: 4632428N05Rik, B7H5, B7-H5, C10orf54, C1H10orf54, C28H10orf54, C4H10orf54, chromosome 10 open reading frame 54, DD1alpha, Death Domain1alpha, Dies1, differentiation of ESCs 1, GI24, PD-1H, PDCD1 homolog, PD-H1, platelet receptor Gi24, PP2135, RIKEN cDNA 4632428N05 gene, SISP1, sisp-1, Stress-induced secreted protein-1, UNQ730/PRO1412, V-domain Ig suppressor of T cell activation, VISTA, V-set domain-containing immunoregulatory receptor, V-set immunoregulatory receptor, VSIR, V-type immunoglobulin domain-containing suppressor of T-cell activation
• Host Species: Rat
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Form: Liquid