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Invitrogen™ VISTA Recombinant Rabbit Monoclonal Antibody (BLR035F)
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Catalog No. PIMA544265
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100 μL
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PIMA544265 100 μL
PIMA544266 10 μL
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Catalog No. PIMA544265 Supplier Invitrogen™ Supplier No. MA544265
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Rabbit Recombinant Monoclonal Antibody

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.

VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is a product of the VSIR gene. Although VISTA bears sequence homology to PD-L1 it has a different expression pattern. In both mouse and humans, VISTA is expressed predominantly on hematopoietic cells with the highest densities on myeloid cells, and lower levels on T cells. It is usually absent on B cells. VISTA expressed by antigen presenting cells has been shown to directly suppress proliferation and cytokine production of CD4 and CD8 T cells, making it a target for cancer immunotherapy. The reported ligands of VISTA include CD28H, VSIG-3 and VSIG-8.
TRUSTED_SUSTAINABILITY

Specifications

Antigen VISTA
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone BLR035F
Concentration 100 μg/mL
Conjugate Unconjugated
Formulation BBS with 0.1% BSA and 0.09% sodium azide; pH 8.2
Gene VSIR
Gene Accession No. Q9H7M9
Gene Alias 4632428N05Rik; B7H5; B7-H5; C10orf54; C1H10orf54; C28H10orf54; C4H10orf54; chromosome 10 open reading frame 54; DD1alpha; Death Domain1alpha; Dies1; differentiation of ESCs 1; GI24; PD-1H; PDCD1 homolog; PD-H1; platelet receptor Gi24; PP2135; RIKEN cDNA 4632428N05 gene; SISP1; sisp-1; Stress-induced secreted protein-1; UNQ730/PRO1412; V-domain Ig suppressor of T cell activation; VISTA; V-set domain-containing immunoregulatory receptor; V-set immunoregulatory receptor; VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation
Gene Symbols VSIR
Host Species Rabbit
Immunogen A peptide representing a region between residue 250 and the C-terminus (residue 311) of human V-type immunoglobulin domain-containing suppressor of T-cell activation precursor.
Purification Method Purified
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 64115
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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WARNING: Cancer - www.P65Warnings.ca.gov
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