Invitrogen™ VNN1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA595389

Catalog No. PIPA595389

Description

Human VNN1 shares 82.2% amino acid (aa) sequence identity with mouse VNN1. Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: SKOV3 whole cell, HELA whole cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Hematopoietic precursor cells migrate to the thymus, where they differentiate into mature T lymphocytes. GPI-anchored vanin-1 protein regulates the late adhesion steps of thymus homing of bone marrow precursor cells. Vanin-1 is ubiquitously expressed as a pantetheinase enzyme and catalyzes the hydrolysis of pantetheine for vitamin B5 recycling. The hydrolytic activity of vanin-1 generates the potent antioxidant cysteamine as a metabolite. As a membrane bound pantetheinase, vanin-1 provides the main source of cysteamine under normal physiological conditions. In mice, vanin-1 is expressed specifically in male Sertoli cells of the developing testis, where it aids in cell migration.

Specifications

• Antigen: VNN1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: VNN1
• Gene Alias: HDLCQ8; Pantetheinase; pantetheine hydrolase; Tiff66; V-1; vanin 1; Vanin1; vanin-1; vannin 1; vascular non-inflammatory molecule 1; VNN1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8876
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 5mg BSA and 0.05mg sodium azide
• Gene Accession No.: O95497
• Gene Symbols: VNN1
• Immunogen: E.coli-derived human VNN1 recombinant protein (Position: Q22-K192).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov