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Tocris Bioscience™ VO-OHpic
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Catalog No. 359150
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Catalog No. Quantity
35-915-0 50 mg
35-911-0 10 mg
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Catalog No. 35-915-0 Supplier Tocris Bioscience™ Supplier No. 3591/50
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Description

Potent PTEN inhibitor

VO-OHpic is a potent inhibitor of PTEN (phosphatase and tensin homolog) (IC50 = 35 nM). Displays selectivity for PTEN over cysteine-based phosphatases such as SopB, MTM, PTPβ and SAC (IC50 values are 588 nM, 4.03, 57.5 and >10 μM respectively). Increases PIP2 and PIP3 levels; also increases Akt translocation in NIH/3T3 fibroblasts. Blocks the immunosuppressant activity of IDO-activated Tregs. Promotes antitumor inflammatory response in combination with immunotherapy and enhances anticancer chemotherapy in tumor-bearing mice.

Specifications

Quantity 50 mg
Product Type VO-OHpic
Purity >98%
Molecular Weight (g/mol) 361.16
Inhibitors VO-OHpic

For Research Use Only

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