Invitrogen™ VPS37A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596833

Catalog No. PIPA596833

Description

Immunogen sequence: MPDVPDAFPE LSELSVSQLT DMNEQEEVLL EQFLTLPQLK QIITDKDDLV KSIEELARKN LLLEPSLEAK RQTVLDKYEL LTQMKSTFEK KMQRQHELSE SCSASALQAR LKVAAHEAEE ESDNIAEDFL EGKMEIDDFL SSFMEKRTIC HCRRAKEEKL QQAIAMHSQF HAPL; Positive Samples: A-549, Jurkat, HepG2; Cellular Location: Late endosome membrane, Nucleus, Peripheral membrane protein.

This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene.

Specifications

• Antigen: VPS37A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Vps37a
• Gene Alias: 2210018P21Rik; 4930592A21Rik; AW261445; D8Ertd531e; ESCRT-I complex subunit VPS37A; HCRP1; Hepatocellular carcinoma-related protein 1; hVps37A; polyglutamine binding protein 2; PQBP2; SPG53; vacuolar protein sorting 37 homolog A; vacuolar protein sorting 37 homolog A (S. cerevisiae); vacuolar protein sorting 37A; vacuolar protein sorting 37A (yeast); vacuolar protein sorting-associated protein 37A; Vps37A; VPS37A, ESCRT-I subunit
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 137492, 290775, 52348
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 2.4 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q8CHS8, Q8NEZ2
• Gene Symbols: Vps37a
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 224-397 of human VPS37A (NP_6896282).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov