Invitrogen™ VPS39 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA588969

Catalog No. PIPA588969

Description

Immunogen sequence: RFHNCLIQLY CEKVQGLMKE YLLSFPAGKT PVPAGEEEGE LGEYRQKLLM FLEISSYYDP GRLICDFPFD GLLEERALLL GRMGKHEQAL FIYVHILKDT RMAEEYCHKH YDRNKDGNKD VYLSLLRMYL SPPSIHCLGP IKLELLEPKA NLQAALQVLE LHHSKLDTTK ALNLLPANTQ INDIRIFLEK VLEENAQKKR FNQVLKNLLH AEFLRVQEER ILHQQVKCII TEEKVCMVCK KKIGNSAFAR YPNGVVVHYF CSKEVNPADT; Positive Samples: U-87MG, 293T, A-549; Cellular Location: Cytoplasm, Late endosome, Late endosome membrane, Lysosome, Lysosome membrane, Peripheral membrane protein.

VPS39 is the mammalian homolog of the yeast vacuolar protein VAM6, that in mammals, promotes lysosome clustering and fusion in vivo. VPS39 is also thought to modulate the TGF-beta response by coupling the TGF-beta receptor complex to the Smad pathway. Similar to the related protein TRAP1, the VPS39 protein is essential for early embryonic development, with mice lacking VPS39 dying at or before E6. 5.

Specifications

• Antigen: VPS39
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: VPS39
• Gene Alias: A230065P22Rik; AW743070; hVam6p; KIAA0770; mVam6; OTTMUSP00000023341; OTTMUSP00000023350; PI3K type 3; Pldn; TLP; TRAP1-like protein; vacuolar protein sorting 39 (yeast); vacuolar protein sorting 39 homolog; vacuolar protein sorting 39 homolog (S. cerevisiae); Vam6; Vam6/Vps39-like protein; Vam6P; Vps39; VPS39 HOPS complex subunit; VPS39, HOPS complex subunit
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23339, 269338, 362199
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 2.01 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q8R5L3, Q96JC1
• Gene Symbols: VPS39
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 606-875 of human VPS39 (NP_0561042).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG